General Cell Lines and Cell Cultures
ATCC Panc 10.05; Pancreatic Carcinoma; Human (Homo sapiens)
Panc 10.05 is an epithelial cell line that was isolated in 1992 from the pancreas of a White, male adult patient with adenocarcinoma. This cell line was deposited by EM Jaffee and can be used in cancer research.
Abcam Astemizole, histamine H1 receptor antagonist and hERG K+ channel blocker, 50MG
MW 458.6 Da, Purity >99%. Potent, selective histamine H1 receptor antagonist (IC50 = 4 nM) and potent hERG K+ channel blocker (IC50 =0.9 nM). Orally active. Antiallergic agent. Active *in vivo* and *in vitro*.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter U2OS XBP1 Nuclear Translocation Cell Line, 2 vials. (93-0857C3)
The PathHunter U2OS XBP1 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the IRE1/XBP1 pathway. This cell line enables assessment of ligand (e.g. thapsigargin) based pathway activation via detection of resulting XBP1 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged XBP1 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of XBP1 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
STEMCELL Technologies Human Peripheral Blood CD19+CD27- Naïve B Cells, Frozen, Size: 1 x 10^6 cells
Primary human CD19+ naïve B cells were isolated from peripheral blood (PB) mononuclear cells (MNCs) using negative immunomagnetic separation techniques. PB was collected using acid-citrate-dextrose solution A (ACDA) as the anticoagulant.Cells were obtained using Institutional Review Board (IRB)-approved consent forms and protocols.Certain products are only available in select territories. Please contact your local Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.Browse our Frequently Asked Questions (FAQs) (https://www.stemcell.com/primary-cells-faq) on Primary Cells.
Eurofins Discoverx PathHunter U2OS HTR2C (VGV) β-Arrestin Cell Line, 2 vials. (93-0932C3)
The PathHunter HTR2C(VGV) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR2C(VGV) GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR2C(VGV) and EA-tagged β-Arrestin-2. Activation of HTR2C(VGV) stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/GITR Stable Cell Line
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) or glucocorticoid-induced TNFR-related protein (GITR) is a protein that in humans is encoded by the TNFRSF18 gene GITR is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Throat, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter PTHR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0770C3)
The PathHunter PTHR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of PTHR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged PTHR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting PTHR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC J.CaM1.6; Acute T Cell Leukemia; Human (Homo sapiens)
J.CaM1.6 (derivative mutant of Jurkat) is a T lymphoblast cell line that was isolated from the peripheral blood of a male patient with acute T cell leukemia. This cell line was deposited by A Weiss and can be used in immune system disorder and immunology research.
Eurofins Discoverx InCELL Hunter HEK 293 PI3Kδ Kinase Binding Cell Line, 2 vials. (96-0061C1)
The InCELL Hunter HEK 293 PI3Kδ Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of PI3Kδ via detection of PI3Kδ levels. This product uses EFC technology. The cell line included overexpresses PI3Kδ target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Medulla oblongata, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter PTGER4 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0772C3)
The PathHunter PTGER4 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of PTGER4 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged PTGER4. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting PTGER4-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CXCR2 (IL8RB) Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0934C3)
The PathHunter CXCR2 (IL8RB) Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CXCR2 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CXCR2 (IL8RB). Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CXCR2 (IL8RB)-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Promocell GmbH PromoCell HSaVEC-c 500,000 Human Saphenous Vein Endothelial Cells, cryopreserved
Primary Human Saphenous Vein Endothelial Cells (HSaVEC) are isolated from human saphenous veins from single donors. The saphenous vein is often used for autotransplantation in coronary artery bypass operations, when arterial grafts are not available or many grafts are required.
ATCC 293TT; Kidney Epithelium; Human (Homo sapiens)
293TT is a cell line exhibiting epithelial morphology that was isolated from a human kidney. It has applications for production of papillomavirus and polyomavirus-based reporter vectors, as well as propagation of torque teno viruses, BK and JC polyomavirus primary isolates.